Ji-Long Chen

time: 2020-09-02   author:   

 

 

Ji-Long Chen, PhD, DVM

Professor of Cellular Microbiology and Immunology,

Dean of College of Animal Sciences(College of Bee Science),

Fujian Agriculture and Forestry University

No. 15 Shangdian Road, Cangshan District

Fuzhou 350002, P.R. China  

E-mail: chenjl@im.ac.cn

  

Education and Training

  

1994-1998:  Postdoctoral training in Molecular Genetics and Cell Biology, Department of Biochemistry, College of Medicine, University of Iowa, USA

1989-1992:  Ph.D. (Molecular and Cell Biology), College of Life Sciences, Peking University, Beijing, China

  

Academic Positions

  

2013-now:    Professor, College of Animal Sciences, Fujian Agriculture and Forestry University, China

2008-now:     Professor, CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), China

2004-2008:    Visiting Research Scientist, Department of Internal Medicine, College of Medicine, University of Iowa, USA.

2000-2004:    Visiting Scholar, Department of Molecular Physiology and Biophysics, Carver College of Medicine, University of Iowa.

1999-2000:    Professor of Cell Biology and Developmental Biology, Institute of Developmental Biology (now its name is Institute of Genetics and Developmental Biology), Chinese Academy of Sciences, Beijing, China

1998-1999:    Associate Professor of Cell Biology and Developmental Biology, Institute of Developmental Biology, Chinese Academy of Sciences, Beijing, China

1993-1994:    Associate Professor of Cell Biology and Developmental Biology, Institute of Developmental Biology, Chinese Academy of Sciences, Beijing, China

1992-1993:    Assistant Professor of Cell Biology and Developmental Biology, Institute of Developmental Biology, Chinese Academy of Sciences, Beijing, China

  

Research Fields

lPathogenic mechanism of viruses such as influenza virus.

lViral infection and host innate immune response.

lThe molecular mechanism of tumorigenesis induced by viruses and oncogenes.

lThe relationship between long non-coding RNAs (lncRNAs) and pathogenic microorganisms.

lThe regulation and mechanism in animal antiviral function.

Honors and Awards

  

1991:     GuangHua Prize, the top honor of Peking University for excellent students

1994:     Second-grade prize for Great Progress in Science and Technology by China Agricultural University

  

1995:    Third-grade prize for Great Progress in Science and Technology by Education Ministry of China

  

1999:     Award for outstanding faculty, Institute of Developmental Biology, Chinese Academy of Sciences, China

2000:     Jilong Chen, nominated by the Chinese Academy of Sciences as an Excellent Young Scientist in China

2002- 2004: Research Award from American Heart Association (AHA)

2015:     Innovation award of Dabei Agricultural Science and Technology Award, China

2018:     Overseas Chinese Contribution Award, China

2018:     Second Prize of Fujian Natural Science Award, China

  

Memberships

   Member, American Society for Cell Biology (ASCB)

Member, American Association for Cancer Research (AACR)

   Member, Chinese Society of Zoology

   Member, Chinese Society of Biotechnology

   Member, Chinese Society of Genetics

Vice President, Veterinary Public Health Branch, Chinese Society of Animal Science and Veterinary Medicine

Vice President, Fujian Association of Animal Husbandry and Veterinary, China

Member, Professional Committee of Veterinary Microbiology, Chinese Society of Microbiology

Standing Member, Animal Infectious Diseases Branch, Chinese Association of Animal Science and Veterinary Medicine

Member, Teaching Steering Committee of Animal Medicine Major in Colleges and Universities of the Ministry of Education, China

List of publications

1.Kul Raj Rai, Biao Chen, Zhonghui Zhao, Yuhai Chen, Jiayue Hu, Shasha Liu, Mohamed Maarouf, Yingying Li, Meng Xiao, Yuan Liao and Ji-Long Chen*.  Robust expression of p27Kip1 induced by viral infection is critical for antiviral innate immunity. Cell Microbiol. 2020, e13242.

2.Yanmei MaXiaoyong ChenKeyuan ChenXiancheng ZengShili YangWei Chang, Yao TangXiaoli ChenSong Wang and Ji-Long Chen*. Identification and Characterization of a Distinct Strain of Beak and Feather Disease Virus in Southeast China. Virol Sin. 2020, 35(1):43-51.

3.Xuefei Wang, Jianling Yang, Guijie Guo, Riyue Feng, Ke Chen, Yuan Liao, Lianfeng Zhang, Liping Sun, Shile Huang and Ji-Long Chen*. Novel lncRNA-IUR suppresses Bcr-Abl-induced tumorigenesis through regulation of STAT5-CD71 pathway. Mol Cancer, 2019, 18(1): 84.

4.Qidong Pan, Zhonghui Zhao, Yuan Liao, Shih-Hsin Chiu, Song Wang, Biao Chen, Na Chen, Yuhai Chen and Ji-Long Chen*. Identification of an interferon-stimulated long noncoding RNA (LncRNA ISR) involved in regulation of influenza A virus replication. Int J Mol Sci. 2019, 20(20): 5118. (*Corresponding author)

5.Guihong Yang*, Huipeng Huang, Mengyao Tang, Zifeng Cai, Cuiqin Huang, Baomin Qi and Ji-Long Chen*. Role of neuromedin B and its receptor in the innate immune responses against influenza A virus infection in vitro and in vivo. Vet Res. 2019, 50(1): 80.

6.Shasha Liu, Ruoxiang Yan, Biao Chen, Qidong Pan, Yuhai Chen, Jinxuan Hong, Lianfeng Zhang, Wenjun Liu, Song Wang and Ji-Long Chen*. Influenza virus-induced robust expression of SOCS3 contributes to excessive production of IL-6. Front Immunol, 2019, 10: 1843.

7.Ye Chen, Quanming Xu, Hong Chen, Xian Luo, Qi Wu, Chen Tan, Qidong Pan and Ji-Long Chen*. Evolution and genetic diversity of porcine circovirus 3 in China. Viruses, 2019, 11(9): 786.

8.Yuan Liao, Mohsan Ullah Goraya, Xu Yuan, Baoge Zhang, Shih-Hsin Chiu and Ji-Long Chen*. Functional involvement of interferon-inducible transmembrane proteins inantiviral immunity. Front Microbiol, 2019, 10: 1097.

9.Mohamed Maarouf, Biao Chen, Yuhai Chen, Xuefei Wang, Kul Raj Rai, Zhonghui Zhao, Shasha Liu, Yingying Li, Meng Xiao and JiLong Chen*. Identification of lncRNA-155 encoded by MIR155HG as a novel regulator of innate immunity against influenza A virus infection. Cell Microbiol, 2019, 21(8): e13036.

10.Jiayue Hu, George Fu Gao and Ji-Long Chen*. Strengthening the role of ethnic minority women in science and medicine in China. Lancet, 2019, 393(10171): 527-528.

11.Yuhai Chen, Jing Ouyang, Ruoxiang Yan, Mohamed Hassan Maarouf, Xuefei Wang, Biao Chen, Shasha Liu, Jiayue Hu, Guijie Guo, Jing Zhang, Sheng-Ming Dai, Huji Xu and Ji-Long Chen*. Silencing SOCS3 mark deteriorates spondyloarthritis in mice induced by minicircle DNA expressing IL23. Front Immunol, 2018, 9: 2641.

12.Song Wang, Lanlan Zhang, Rong Zhang, Xiaojuan Chi, Zhou Yang, Yanhui Xie, Sicheng Shu, Yuan Liao and Ji-Long Chen*. Identification of two residues within the NS1 of H7N9 influenza A virus that critically affect the protein stability and function. Vet Res, 2018, 49(1):98.

13.Riyue Feng, Xuefei Wang, Jianning Li, Ke Chen, Guijie Guo, Yuan Liao, Liping Sun, Shile Huang and Ji-Long Chen*. Interaction of Abl tyrosine kinases with SOCS3 impairs its suppressor function in  tumorigenesis. Neoplasia, 2018, 20(11): 1095-1105.

14.Mohamed Maarouf, Kul Raj Rai, Mohsan Ullah Goraya and Ji-Long Chen*. Immune ecosystem of virus-infected host tissues. Int J Mol Sci, 2018, 19(5): 1379.

15.Xiaoyong Chen, Shasha Liu, Mohsan Ullah Goraya, Mohamed Maarouf, Shile Huang and Ji-Long Chen*. Host immune response to influenza A virus infection. Front Immunol, 2018, 9: 320.

16.Ye Chen, Jin Tian and Ji-Long Chen*. Challenges to eliminate rabies virus infection in China by 2020. Lancet Infect Dis, 2017, 17(2): 135-136.

17.Binxiang Cai, Qingling Bai, Xiaojuan Chi, Mohsan U. Goraya, Long Wang, Song Wang, Biao Chen and Ji-Long Chen*. Infection with classical swine fever virus induces expression of type III interferons and activates innate immune signaling. Front Microbiol. 2017, 8: 2558.

18.Ye Chen, Xinxin Li, Xiaojuan Chi, Song Wang, Yanmei Ma and Ji-Long Chen*. Comprehensive analysis of the codon usage patterns in the envelope glycoprotein E2 gene of the classical swine fever virus. PLoS ONE, 2017, 12(9): e0183646.

19.Ye Chen, Quanming Xu, Chen Tan, Xinxin Li, Xiaojuan Chi, Binxiang Cai, Ziding Yu, Yanmei Ma and Ji-Long Chen*. Genomic analysis of codon usage shows influence of mutation pressure, natural selection, and host features on Senecavirus A evolution. Microb Pathog. 2017, 112: 313-319.

20.Shilong Chen, Long Wang, Jieying Chen, Lanlan Zhang, Song Wang, Mohsan Ullah Goraya, Xiaojuan Chi, Yang Na, Wenhan Shao, Zhou Yang, Xiancheng Zeng, Shaoying Chen and Ji-Long Chen*. Avian interferon-inducible transmembrane protein family effectively restricts avian tembusu virus infection. Front Microbiol, 2017, 8: 672.

21.Jingyun Wei, Yanmei Ma, Long Wang, Xiaojuan Chi, Ruoxiang Yan, Song Wang, Xinxin Li, Xiaoyong Chen, Wenhan Shao and Ji-Long Chen*. Alpha/beta interferon receptor deficiency in mice significantly enhances susceptibility of the animals to pseudorabies virus infection. Vet Microbiol, 2017, 203: 234.

22.Wenhan Shao, Xinxin Li, Mohsan Ullah Goraya, Song Wang* and Ji-Long Chen*. Evolution of influenza A virus by mutation and re-assortment. Int J Mol Sci, 2017, 18(8):1650.

23.Lanlan Zhang, Jingyun Wei, Long Wang, Shile Huang and Ji-long Chen*. Human T-cell lymphotropic virus type 1 and its oncogenesis. Acta Pharmacol Sin, 2017, 38(8): 1093-1103.

24.Xuefei Wang, Shile Huang and Ji-Long Chen*. Understanding of leukemic stem cells and their clinical implications. Mol Cancer, 2017, 16(1): 2.

25.Yanmei Ma, Jing Ouyang, Jingyun Wei, Mohamed Maarouf and Ji-Long Chen*. Involvement of host non-coding RNAs in the pathogenesis of the influenza virus. Int J Mol Sci, 2017, 18(1): 39.

26.Song Wang, Xiaoqin Luo, Ruoxiang Yan, Quanxin Wang, Qiuyue Qi, Xiaojuan Chi, Lanlan Zhang, Ziding Yu, Binxiang Cai, Ji-Long Chen* and Hongwei Liu*. 3-Anhydro-6-hydroxy-ophiobolin A displays high in vitro and in vivo efficacy against influenza A virus infection. Protein & Cell, 2016, 7(11): 839-843.

27.Shi-long Chen, Guifeng Luo, Zhou Yang, Shuncheng Lin, Shaoying Chen, Song Wang, Mohsan Ulah Goraya, Xiaojuan Chi, Xianchegn Zeng and Ji-Long Chen*. Avian Tembusu virus infection effectively triggers host innate immune response through MDA5 and TLR3-dependent signaling pathways. Vet Res, 2016, 47(1): 74.

28.Xiancheng Zeng, Song Wang, Xiaojuan Chi, Shi-long Chen, Shile Huang, Qunqun Lin, Ji-Long Chen* and Baogui Xie*. Infection of goats with goatpox virus triggers host antiviral defense through activation of innate immune signaling. Res Vet Sci, 2016, 104: 40-49.

29.Jing Ouyang, Jiayue Hu and Ji-long Chen*. lncRNAs regulate the innate immune response to viral infection. Wiley Interdiscip Rev RNA, 2016, 7(1): 129-143.

30.Xuefei Wang, Ke Chen, Guijie Guo and Ji-Long Chen*. Noncoding RNAs and their functional involvement in regulation of chronic myeloid leukemia. Brief Funct Genomics, 2015, 15(3): 239-248.

31.Song Wang, Chao Chen, Zhou Yang, Xiaojuan Chi, Jing Zhang and Ji-Long Chen*. Targeted disruption of influenza A virus hemagglutinin in genetically modified mice reduces viral replication and improves disease outcome. Sci Rep, 2016, 6: 23746.

32.Mohsan Ullah Goraya, Song Wang, Muhammad Munir and Ji-Long Chen*. Induction of innate immunity and its perturbation by influenza viruses. Protein & Cell, 2015, 6(10): 712–721.

33.Guijie Guo, Qingzheng Kang, Xiaomei Zhu, Qinghuang Chen, Xuefei Wang, Yuhai Chen, Jing Ouyang, Lianfeng Zhang, Huo Tan, Runsheng Chen, Shile Huang and Ji-Long Chen*. A long noncoding RNA critically regulates Bcr-Abl-mediated cellular transformation by acting as a competitive endogenous RNA. Oncogene, 2015, 34(14): 1768-1779.

34.Zhilong Chen, Guifeng Luo, Quanxi Wang*, Song Wang*, Xiaojuan Chi, Yifan Huang, Haitao Wei, Baocheng Wu, Shile Huang and Ji-Long Chen*. Muscovy duck reovirus infection rapidly activates host innate immune signaling and induces an effective antiviral immune response involving critical interferons. Vet Microbiol, 2015, 175(2-4):232-243.

35.Fang Li#, Yuhai Chen#, Zhaoyuan Zhang#, Jing Ouyang, Yi Wang, Ruoxiang Yan, Shile Huang, George Fu Gao, Guijie Guo and Ji-Long Chen*. Robust expression of vault RNAs induced by influenza A virus plays a critical role in suppression of PKR-mediated innate immunity. Nucleic Acids Res, 2015, 43(21): 10321–10337.

36.Jing Ouyang, Xiaomei Zhu, Yuhai Chen, Haitao Wei, Qinghuang Chen, Xiaojuan Chi, Baomin Qi, Lianfeng Zhang, Yi Zhao, George F. Gao, Guoshun Wang and Ji-Long Chen*. NRAV, a long noncoding RNA, modulates antiviral responses through suppression of interferon-stimulated gene transcription. Cell Host & Microbe, 2014, 16 (5): 616-626.

37.Haitao Wei, Song Wang, Qinghuang Chen, Yuhai Chen, Xiaojuan Chi, Lianfeng Zhang, Shile Huang, George F. Gao and Ji-Long Chen*. Suppression of interferon lambda signaling by SOCS-1 results in their excessive production during influenza virus infection. PLoS Pathog2014, 10(1): e1003845.

38.Qinghuang Chen, Ke Chen, Guijie Guo, Fang Li, Chao Chen, Song Wang, Nalepa Grzegorz, Shile Huang and Ji-LongChen*. A critical role of CDKN3 in Bcr-Abl-mediated tumorigenesis.PLoS ONE, 2014, 9(10): e111611.

39.Guijie Guo, Qingzheng Kang, Qinghuang Chen, Zhilong Chen, Jun Wang, Li Tan and Ji-Long Chen*. High expression of long non-coding RNA H19 is required for efficient tumorigenesis induced by Bcr-Abl oncogene. FEBS Lett, 2014, 588(9): 1780-1786.

40.Song Wang, Xiaojuan Chi, Haitao Wei, Yuhai Chen, Zhilong Chen, Shile Huang and Ji-Long Chen*. Influenza A virus-induced degradation of eukaryotic translation initiation factor 4B contributes to viral replication by suppressing IFITM3 protein expression. J Virol, 2014, 88(15): 8375-8385.

41.Quanxi Wang, Yaping Wen, Yifan Huang, Yijian Wu, Yilong Cai, Lihui Xu, Changkang Wang, Ang Li, Baocheng Wu and Ji-Long Chen. Isolation and identification of Duck tembusu virus strain LH and development of latex-agglutination diagnostic method for rapid detection of antibodies. Avian Dis, 2014, 58(4): 616-622.

42.Guomin Qian, Song Wang, Xiaojuan Chi, Hua Li, Haitao Wei, Xiaomei Zhu, Yuhai Chen and Ji-Long Chen*. The amino-terminal region of the neuraminidase protein from avian H5N1 influenza virus is important for its biosynthetic transport to the host cell surface. Vet J, 2014, 202(3): 612-617.

43.Rong Zhang, Xiaojuan Chi, Song Wang, Baomin Qi, Xiaoqiang Yu and Ji-Long Chen*. The regulation of autophagy by influenza A virus. Biomed Res Int, 2014, 2014(7): 498083.

44.Quanxin Wang, Jianling Yang, Qiuyue Qi, Li Bao, Xiaoli Yang, Miaomiao Liu, Pei Huang, Lixin Zhang*, Ji-Long Chen*, Lei Cai, and Hong-Wei Liu*. 3-Anhydro-6-hydroxy-ophiobolin A, a new sesterterpene inhibiting the growth of methicillin-resistant Staphylococcus aureus and inducing the cell death by apoptosis on K562, from the phytopathogenic fungus Bipolaris oryzae. Bioorg Med Chem Lett, 2013, 23(12): 3547-3550.

45.Jianling Yang, Jun Wang, Ke Chen, Guijie Guo, Ruijiao Xi, Paul B. Rothman, Douglas Whitten, Lianfeng Zhang, Shile Huang, and Ji-Long Chen*. eIF4B Phosphorylation by pim kinases plays a critical role in cellular transformation by Abl oncogenes. Cancer Res, 2013, 73(15): 4898-4908.

46.Xiaojuan Chi, Song Wang, Yifan Huang, Mark Stamnes and Ji-Long Chen*.Roles of Rho GTPases in intracellular transport and cellular transformation.Int J Mol Sci, 2013, 14 (4): 7089-7108.

47.Ke Chen, Ying-hui Huang and Ji-long Chen*. Understanding and targeting cancer stem cells: therapeutic implications and challenges. Acta Pharmacol Sin, 2013, 34(6): 732-740.

48.Xiaoxue Qiu, Guijie Guo, Ke Chen, Masaki Kashiwada, Brian J. Druker, Paul B. Rothman* and Ji-Long Chen*. A requirement for SOCS-1 and SOCS-3 phosphorylation in Bcr-Abl-induced tumorigenesis. Neoplasia, 2012, 14(6): 547-558.

49.Kewei Fan#, Yinping Jia#, Song Wang, Hua Li, Defeng Wu, Guoshun Wang and Ji-Long Chen*. Role of Itk signalling in the interaction between influenza A virus and T-cells. J Gen Virol, 2012, 93(Pt 5):987-997.

50.Song Wang#, Hua Li#, Yuhai Chen#, Haitao Wei, George F. Gao, Hongqiang Liu, Shile Huang and Ji-long Chen*. Transport of influenza virus neuraminidase (NA) to host cell surface is regulated by ARHGAP21 and Cdc42 proteins. J Biol Chem, 2012, 287(13): 9804-9816.

51.Guijie Guo#, Xiaoxue Qiu#, Song Wang#, Yuhai Chen, Paul B. Rothman, Zixu Wang, Yaoxing Chen, Guoshun Wang and Ji-Long Chen*. The oncogenic E17K mutation in the pleckstrin homology domain of AKT1 promotes v-Abl-mediated pre-B cell transformation and survival of Pim-deficient cells. Oncogene, 2010, 29(26): 3845-3853.